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SIGNALING PATHWAY
JAK
Bcl-2
TNF-alpha
Mdm2
Survivin
p53
Caspase
IAP
PERK
PI3K/Akt/mTOR
PI3K
mTOR
Akt
GSK-3
PDK-1
PKA
AMPK
S6 Kinase
Epigenetics
HDAC
Sirtuin
DNA Methyltransferase
Epigenetic Reader Domain
Histone Methyltransferase
Histone demethylases
Histone Acetyltransferase
Protein Tyrosine Kinase
VEGFR
EGFR
IGF-1R
Bcr-Abl
HER2
PDGFR
c-Kit
c-Met
ALK
Tie-2
Ephrin receptor
Axl
Trk receptor
CSF-1R
Angiogenesis
Src
FLT3
VDA
HIF
FGFR
Syk
FAK
BTK
Apoptosis
Bcl-2
TNF-alpha
Mdm2
Survivin
p53
Caspase
IAP
PERK
Autophagy
JAK/STAT
STAT
Pim
MAPK
MEK
p38 MAPK
Raf
JNK
ERK
Cytoskeletal Signaling
HSP (e.g. HSP90)
Microtubule Associated
Kinesin
PAK
Cell Cycle
Aurora Kinase
ROCK
PLK
CDK
Rho
Wee1
Chk
APC
c-Myc
TGF-beta/Smad
PKC
TGF-beta/Smad
DNA Damage
PARP
ATM/ATR
DNA/RNA Synthesis
Telomerase
Topoisomerase
PPAR
DNA-PK
Stem Cells & Wnt
Hedgehog/Smoothened
Wnt/beta-catenin
Ubiquitin
E3 Ligase
p97
E1 Activating
E2 conjugating
Neuronal Signaling
GluR
Opioid Receptor
GABA Receptor
Adrenergic Receptor
5-HT Receptor
P2 Receptor
COX
Dopamine Receptor
AMPA Receptor-kainate Receptor-NMDA Receptor
AChR
Histamine Receptor
Beta Amyloid
NF-κB Signaling
IκB/IKK
NOD1
NF-κB
GPCR & G Protein
5-HT Receptor
Adrenergic Receptor
Histamine Receptor
Opioid Receptor
Cannabinoid Receptor
S1P Receptor
Hedgehog/Smoothened
SGLT
OX Receptor
CGRP Receptor
MT Receptor
PAFR
CXCR
Vasopressin Receptor
cAMP
Adenosine Receptor
Dopamine Receptor
Endothelin Receptor
CaSR
LPA Receptor
Protease-Activated Receptor
Prostaglandin Receptor
Endocrinology & Hormones
Aromatase
Estrogen/progestogen Receptor
Androgen Receptor
5-alpha Reductase
RAAS
GPR
Transmembrane Transporters
CFTR
Sodium Channel
Calcium Channel
Proton Pump
Potassium Channel
ATPase
P-gp
CRM1
Metabolism
Factor Xa
Phospholipase (e.g. PLA)
P450 (e.g. CYP17)
DHFR
PDE
Carbonic Anhydrase
Hydroxylase
Dehydrogenase
Transferase
MAO
Aminopeptidase
HMG-CoA Reductase
Procollagen C Proteinase
FAAH
Phosphorylase
CETP
IDO
Ferroptosis
Proteases
Proteasome
DPP-4
Cysteine Protease
HCV Protease
HIV Protease
Gamma-secretase
BACE
MMP
DUB
Serine Protease
Microbiology
Integrase
CCR
Reverse Transcriptase
Others
Substance P
IL Receptor
Lysyl Hydroxylase
Thrombin
Liver X Receptor
gp120/CD4
FXR
TRPV
Integrin
Dynamin
Other inhibitors
Metabolism
Factor Xa
(0)
Phospholipase (e.g. PLA)
(1)
P450 (e.g. CYP17)
(1)
DHFR
(0)
PDE
(0)
Carbonic Anhydrase
(1)
Hydroxylase
(2)
Dehydrogenase
(5)
Transferase
(1)
MAO
(1)
Aminopeptidase
(0)
HMG-CoA Reductase
(0)
Procollagen C Proteinase
(0)
FAAH
(0)
Phosphorylase
(0)
CETP
(1)
IDO
(3)
Ferroptosis
(1)
Product number
Product Name
CAS No.
MW
Purity
P1446502-11-9
AG-221(Enasidenib)
1446502-11-9
473.38
98%+
1
2
