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SIGNALING PATHWAY
JAK
Bcl-2
TNF-alpha
Mdm2
Survivin
p53
Caspase
IAP
PERK
PI3K/Akt/mTOR
PI3K
mTOR
Akt
GSK-3
PDK-1
PKA
AMPK
S6 Kinase
Epigenetics
HDAC
Sirtuin
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Epigenetic Reader Domain
Histone Methyltransferase
Histone demethylases
Histone Acetyltransferase
Protein Tyrosine Kinase
VEGFR
EGFR
IGF-1R
Bcr-Abl
HER2
PDGFR
c-Kit
c-Met
ALK
Tie-2
Ephrin receptor
Axl
Trk receptor
CSF-1R
Angiogenesis
Src
FLT3
VDA
HIF
FGFR
Syk
FAK
BTK
Apoptosis
Bcl-2
TNF-alpha
Mdm2
Survivin
p53
Caspase
IAP
PERK
Autophagy
JAK/STAT
STAT
Pim
MAPK
MEK
p38 MAPK
Raf
JNK
ERK
Cytoskeletal Signaling
HSP (e.g. HSP90)
Microtubule Associated
Kinesin
PAK
Cell Cycle
Aurora Kinase
ROCK
PLK
CDK
Rho
Wee1
Chk
APC
c-Myc
TGF-beta/Smad
PKC
TGF-beta/Smad
DNA Damage
PARP
ATM/ATR
DNA/RNA Synthesis
Telomerase
Topoisomerase
PPAR
DNA-PK
Stem Cells & Wnt
Hedgehog/Smoothened
Wnt/beta-catenin
Ubiquitin
E3 Ligase
p97
E1 Activating
E2 conjugating
Neuronal Signaling
GluR
Opioid Receptor
GABA Receptor
Adrenergic Receptor
5-HT Receptor
P2 Receptor
COX
Dopamine Receptor
AMPA Receptor-kainate Receptor-NMDA Receptor
AChR
Histamine Receptor
Beta Amyloid
NF-κB Signaling
IκB/IKK
NOD1
NF-κB
GPCR & G Protein
5-HT Receptor
Adrenergic Receptor
Histamine Receptor
Opioid Receptor
Cannabinoid Receptor
S1P Receptor
Hedgehog/Smoothened
SGLT
OX Receptor
CGRP Receptor
MT Receptor
PAFR
CXCR
Vasopressin Receptor
cAMP
Adenosine Receptor
Dopamine Receptor
Endothelin Receptor
CaSR
LPA Receptor
Protease-Activated Receptor
Prostaglandin Receptor
Endocrinology & Hormones
Aromatase
Estrogen/progestogen Receptor
Androgen Receptor
5-alpha Reductase
RAAS
GPR
Transmembrane Transporters
CFTR
Sodium Channel
Calcium Channel
Proton Pump
Potassium Channel
ATPase
P-gp
CRM1
Metabolism
Factor Xa
Phospholipase (e.g. PLA)
P450 (e.g. CYP17)
DHFR
PDE
Carbonic Anhydrase
Hydroxylase
Dehydrogenase
Transferase
MAO
Aminopeptidase
HMG-CoA Reductase
Procollagen C Proteinase
FAAH
Phosphorylase
CETP
IDO
Ferroptosis
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Cysteine Protease
HCV Protease
HIV Protease
Gamma-secretase
BACE
MMP
DUB
Serine Protease
Microbiology
Integrase
CCR
Reverse Transcriptase
Others
Substance P
IL Receptor
Lysyl Hydroxylase
Thrombin
Liver X Receptor
gp120/CD4
FXR
TRPV
Integrin
Dynamin
Other inhibitors
MEK
Product number
Product Name
CAS No.
MW
Purity
P606143-52-6
Selumetinib (AZD6244)
606143-52-6
457.68
99.00%
P606143-89-9
Binimetinib (MEK-162, ARRY-162, ARRY-438162)
606143-89-9
441.23
98%+
