 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 900185-02-6 |
| Molecular formula(MF) | C28H23N7O2 |
| Molecular Weight(MW): | 489.53 |
| Alias |
| In vitro | DMSO | 98 mg/mL (200.19 mM) |
|---|---|---|
| Water | <1 mg/mL | |
| Ethanol | <1 mg/mL |
| Description | PIK-294 is a highly selective p110δ inhibitor with IC50 of 10 nM, 1000-, 49- and 16-fold less potent to PI3Kα/β/γ, respectively. | ||||||
|---|---|---|---|---|---|---|---|
| Features | A p110δ inhibitor. | ||||||
| Targets |
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| In vitro |
PIK-294 shows distinct patterns of isoform selectivity to inhibit different subsets of class I PI3K isoforms (p110β, p110δ, and p110γ) and exhibits low sensitivity to p110α with IC50 of 10 μM). The m-phenol moiety of PIK-294 is able to penetrate the deep-affinity pocket of the ATP binding site, and thus increases in vitro inhibitory activity. [1] |