 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 896705-16-1 |
| Molecular formula(MF) | C21H20N4O2 |
| Molecular Weight(MW): | 360.41 |
| Alias | EU-0061988; NSC751342; 12H-Benzo[g]pyrido[2, N-[2(dimethylamino)ethyl]-12-oxo; SureCN13248367; AKOS005021577; AC1MQV6O; |
| In vitro | DMSO | 5 mg/mL warmed (13.87 mM) |
|---|---|---|
| Ethanol | 2 mg/mL warmed (5.54 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. | |
|---|---|---|
| Targets |
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| In vitro |
BMH-21 causes proteasome-dependent destruction of RPA194, the large catalytic subunit protein of Pol I holocomplex. [1] In U2OS cancer cell line, BMH-21 results in degradation of RPA194 and translocation of NCL with IC50 of 0.05 μM and 0.07 μM, respectively. By causing nucleolar stress, BMH-21 also shows potent inhibition on cell viability. [2] |
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| In vivo | BMH-21 reduces tumor growth in mouse xenografts. [1] |