 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 89464-63-1 |
| Molecular formula(MF) | C6H9NO5 |
| Molecular Weight(MW): | 175.14 |
| Alias |
| In vitro | DMSO | 35 mg/mL (199.84 mM) |
|---|---|---|
| Water | 35 mg/mL (199.84 mM) | |
| Ethanol | 35 mg/mL (199.84 mM) | |
| In vivo |
| Description | DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase. | |
|---|---|---|
| Targets |
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| In vitro |
DMOG shows only weakly active in the microsomal system, but efficiently suppresses hydroxyproline synthesis in intact cells. [1] DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC. [3] |
|
| In vivo | DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. [2] Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats. [4] |