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AZD7762

(CAS No:860352-01-8)
AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.
CAS No:860352-01-8
Molecular Weight(MW):362.42
Purity:99.00%
Specification:500MG;1G;5G;10G;50G;100G
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QC Documents
 COA  MSDS  HPLC  NMR
ChemicalInfomation
CAS No: 860352-01-8
Molecular formula(MF) C17H19FN4O2S
Molecular Weight(MW): 362.42
Alias 5-(3-Fluorophenyl)-3-ureidothiophene-N-[(S)-piperidin-3-yl]-2-carboxamide
Solubility
In vitro DMSO 50 mg/mL (137.96 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
Biological Activity
Description AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.
Targets
Chk1 [1]
(Cell-free assay)
Chk2 [1]
(Cell-free assay)
5 nM <10 nM
In vitro

AZD7762, a more selective Chk1 inhibitor, inhibits Chk1 phosphorylation of a cdc25C peptide by reversibly binding to the ATP-binding site of Chk1, with IC50 of 5 nM and Ki of 3.6 nM. AZD7762 induces cell arrest with EC50 of 0.620 μM, and significantly abrogates the camptothecin induced G2 arrest with an EC50 of 10 nM, by blocking the chk1 dependent degradation of Cdc25A and activation of Cyclin A. AZD7762 (300 nM) enhances the antitumor efficacy of gemcitabine against SW620 and topotecan against MDA-MB-231 by reducing the GI50 values from 24.1 nM and 2.25 μM to 1.08 nM and 0.15 μM, respectively. [1] AZD7762 shows cytotoxicity against a variety of neuroblastoma cell lines bearing p53 wild type, p53 mutation, Mdm2 amplification or p14 deletion with IC50 values ranging from 82.6-505.9 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KASUMI-1 Growth Inhibition Assay IC50=0.000234 μM SANGER
NKM-1 Growth Inhibition Assay IC50=0.000415 μM SANGER
MV-4-11 Growth Inhibition Assay IC50=0.000425 μM SANGER
NCI-H1703 Growth Inhibition Assay IC50=0.00643 μM SANGER
A204 Growth Inhibition Assay IC50=0.00856 μM SANGER
CGTH-W-1 Growth Inhibition Assay IC50=0.0142 μM SANGER
MLMA Growth Inhibition Assay IC50=0.02849 μM SANGER
GOTO Growth Inhibition Assay IC50=0.0312 μM SANGER
KE-37 Growth Inhibition Assay IC50=0.03142 μM SANGER
ES4 Growth Inhibition Assay IC50=0.03251 μM SANGER
ATN-1 Growth Inhibition Assay IC50=0.03417 μM SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=0.03442 μM SANGER
SW756 Growth Inhibition Assay IC50=0.03579 μM SANGER
CTV-1 Growth Inhibition Assay IC50=0.03896 μM SANGER
HCC1806 Growth Inhibition Assay IC50=0.04022 μM SANGER
NEC8 Growth Inhibition Assay IC50=0.04203 μM SANGER
P12-ICHIKAWA Growth Inhibition Assay IC50=0.04316 μM SANGER
DEL Growth Inhibition Assay IC50=0.04592 μM SANGER
KM12 Growth Inhibition Assay IC50=0.05158 μM SANGER
LB1047-RCC Growth Inhibition Assay IC50=0.06025 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50=0.06102 μM SANGER
NOMO-1 Growth Inhibition Assay IC50=0.06115 μM SANGER
NB14 Growth Inhibition Assay IC50=0.06136 μM SANGER
ONS-76 Growth Inhibition Assay IC50=0.06196 μM SANGER
HD-MY-Z Growth Inhibition Assay IC50=0.06255 μM SANGER
G-402 Growth Inhibition Assay IC50=0.0646 μM SANGER
ES1 Growth Inhibition Assay IC50=0.07146 μM SANGER
L-363 Growth Inhibition Assay IC50=0.0739 μM SANGER
A4-Fuk Growth Inhibition Assay IC50=0.07486 μM SANGER
OC-314 Growth Inhibition Assay IC50=0.07807 μM SANGER
SK-LU-1 Growth Inhibition Assay IC50=0.08421 μM SANGER
MDA-MB-157 Growth Inhibition Assay IC50=0.08659 μM SANGER
HuP-T3 Growth Inhibition Assay IC50=0.0871 μM SANGER
A3-KAW Growth Inhibition Assay IC50=0.08806 μM SANGER
MOLT-16 Growth Inhibition Assay IC50=0.08807 μM SANGER
COLO-679 Growth Inhibition Assay IC50=0.09091 μM SANGER
EM-2 Growth Inhibition Assay IC50=0.09903 μM SANGER
ES8 Growth Inhibition Assay IC50=0.09918 μM SANGER
SK-MEL-2 Growth Inhibition Assay IC50=0.10033 μM SANGER
ES3 Growth Inhibition Assay IC50=0.102 μM SANGER
HSC-4 Growth Inhibition Assay IC50=0.10554 μM SANGER
697 Growth Inhibition Assay IC50=0.11063 μM SANGER
TGBC11TKB Growth Inhibition Assay IC50=0.11093 μM SANGER
SK-PN-DW Growth Inhibition Assay IC50=0.1186 μM SANGER
H9 Growth Inhibition Assay IC50=0.12165 μM SANGER
NCI-H2122 Growth Inhibition Assay IC50=0.1225 μM SANGER
ML-2 Growth Inhibition Assay IC50=0.12484 μM SANGER
MC-IXC Growth Inhibition Assay IC50=0.12843 μM SANGER
KYSE-140 Growth Inhibition Assay IC50=0.13041 μM SANGER
DOHH-2 Growth Inhibition Assay IC50=0.13064 μM SANGER
MEL-JUSO Growth Inhibition Assay IC50=0.13128 μM SANGER
P30-OHK Growth Inhibition Assay IC50=0.1316 μM SANGER
CTB-1 Growth Inhibition Assay IC50=0.13325 μM SANGER
ACHN Growth Inhibition Assay IC50=0.13369 μM SANGER
ES5 Growth Inhibition Assay IC50=0.13476 μM SANGER
SF539 Growth Inhibition Assay IC50=0.1368 μM SANGER
D-283MED Growth Inhibition Assay IC50=0.13687 μM SANGER
OVCAR-5 Growth Inhibition Assay IC50=0.13894 μM SANGER
RPMI-8866 Growth Inhibition Assay IC50=0.13925 μM SANGER
PANC-03-27 Growth Inhibition Assay IC50=0.14288 μM SANGER
M14 Growth Inhibition Assay IC50=0.14463 μM SANGER
D-566MG Growth Inhibition Assay IC50=0.1469 μM SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50=0.14842 μM SANGER
NOS-1 Growth Inhibition Assay IC50=0.14967 μM SANGER
YH-13 Growth Inhibition Assay IC50=0.15674 μM SANGER
NB17 Growth Inhibition Assay IC50=0.15786 μM SANGER
U-2-OS Growth Inhibition Assay IC50=0.15847 μM SANGER
ES7 Growth Inhibition Assay IC50=0.16011 μM SANGER
LoVo Growth Inhibition Assay IC50=0.16166 μM SANGER
QIMR-WIL Growth Inhibition Assay IC50=0.16311 μM SANGER
ESS-1 Growth Inhibition Assay IC50=0.16413 μM SANGER
LAMA-84 Growth Inhibition Assay IC50=0.16503 μM SANGER
TGBC24TKB Growth Inhibition Assay IC50=0.16535 μM SANGER
KU812 Growth Inhibition Assay IC50=0.1683 μM SANGER
KARPAS-45 Growth Inhibition Assay IC50=0.16847 μM SANGER
ACN Growth Inhibition Assay IC50=0.17171 μM SANGER
RPMI-8226 Growth Inhibition Assay IC50=0.17464 μM SANGER
GR-ST Growth Inhibition Assay IC50=0.17827 μM SANGER
SK-UT-1 Growth Inhibition Assay IC50=0.18599 μM SANGER
SK-N-AS Growth Inhibition Assay IC50=0.18815 μM SANGER
EW-1 Growth Inhibition Assay IC50=0.18905 μM SANGER
5637 Growth Inhibition Assay IC50=0.19278 μM SANGER
GI-1 Growth Inhibition Assay IC50=0.19561 μM SANGER
NCI-H1395 Growth Inhibition Assay IC50=0.19761 μM SANGER
CHP-212 Growth Inhibition Assay IC50=0.19782 μM SANGER
A427 Growth Inhibition Assay IC50=0.19832 μM SANGER
BE-13 Growth Inhibition Assay IC50=0.20117 μM SANGER
RS4-11 Growth Inhibition Assay IC50=0.20318 μM SANGER
TI-73 Growth Inhibition Assay IC50=0.20873 μM SANGER
HAL-01 Growth Inhibition Assay IC50=0.2097 μM SANGER
KY821 Growth Inhibition Assay IC50=0.21429 μM SANGER
H4 Growth Inhibition Assay IC50=0.22062 μM SANGER
EPLC-272H Growth Inhibition Assay IC50=0.22068 μM SANGER
COR-L105 Growth Inhibition Assay IC50=0.22235 μM SANGER
769-P Growth Inhibition Assay IC50=0.22298 μM SANGER
HEL Growth Inhibition Assay IC50=0.22454 μM SANGER
VA-ES-BJ Growth Inhibition Assay IC50=0.22557 μM SANGER
IST-MEL1 Growth Inhibition Assay IC50=0.2257 μM SANGER
KYSE-270 Growth Inhibition Assay IC50=0.22633 μM SANGER
RH-1 Growth Inhibition Assay IC50=0.22666 μM SANGER
JVM-3 Growth Inhibition Assay IC50=0.23036 μM SANGER
RPMI-7951 Growth Inhibition Assay IC50=0.23056 μM SANGER
JAR Growth Inhibition Assay IC50=0.23238 μM SANGER
MOLT-4 Growth Inhibition Assay IC50=0.2385 μM SANGER
ALL-PO Growth Inhibition Assay IC50=0.24243 μM SANGER
SNU-387 Growth Inhibition Assay IC50=0.24339 μM SANGER
IGROV-1 Growth Inhibition Assay IC50=0.24401 μM SANGER
MPP-89 Growth Inhibition Assay IC50=0.24451 μM SANGER
T98G Growth Inhibition Assay IC50=0.24568 μM SANGER
NCI-H510A Growth Inhibition Assay IC50=0.24626 μM SANGER
KOSC-2 Growth Inhibition Assay IC50=0.24671 μM SANGER
NCI-H23 Growth Inhibition Assay IC50=0.24761 μM SANGER
MC116 Growth Inhibition Assay IC50=0.25654 μM SANGER
8-MG-BA Growth Inhibition Assay IC50=0.25768 μM SANGER
ABC-1 Growth Inhibition Assay IC50=0.26064 μM SANGER
J-RT3-T3-5 Growth Inhibition Assay IC50=0.26678 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=0.27059 μM SANGER
HCC1395 Growth Inhibition Assay IC50=0.27089 μM SANGER
BB65-RCC Growth Inhibition Assay IC50=0.27097 μM SANGER
NCI-H1755 Growth Inhibition Assay IC50=0.27304 μM SANGER
OVCAR-3 Growth Inhibition Assay IC50=0.27385 μM SANGER
MKN45 Growth Inhibition Assay IC50=0.2798 μM SANGER
TYK-nu Growth Inhibition Assay IC50=0.2806 μM SANGER
SNU-C2B Growth Inhibition Assay IC50=0.28134 μM SANGER
H-EMC-SS Growth Inhibition Assay IC50=0.28354 μM SANGER
CAKI-1 Growth Inhibition Assay IC50=0.2868 μM SANGER
EW-24 Growth Inhibition Assay IC50=0.2891 μM SANGER
RXF393 Growth Inhibition Assay IC50=0.29008 μM SANGER
CCRF-CEM Growth Inhibition Assay IC50=0.29154 μM SANGER
HOP-92 Growth Inhibition Assay IC50=0.29279 μM SANGER
COLO-684 Growth Inhibition Assay IC50=0.29406 μM SANGER
NCI-H28 Growth Inhibition Assay IC50=0.29704 μM SANGER
HuO9 Growth Inhibition Assay IC50=0.29793 μM SANGER
SF295 Growth Inhibition Assay IC50=0.29802 μM SANGER
COLO-829 Growth Inhibition Assay IC50=0.29845 μM SANGER
MSTO-211H Growth Inhibition Assay IC50=0.29855 μM SANGER
MDA-MB-361 Growth Inhibition Assay IC50=0.29896 μM SANGER
FTC-133 Growth Inhibition Assay IC50=0.30265 μM SANGER
Mewo Growth Inhibition Assay IC50=0.30431 μM SANGER
HCC70 Growth Inhibition Assay IC50=0.30665 μM SANGER
BB30-HNC Growth Inhibition Assay IC50=0.31525 μM SANGER
LCLC-97TM1 Growth Inhibition Assay IC50=0.31566 μM SANGER
HCC2998 Growth Inhibition Assay IC50=0.3165 μM SANGER
NBsusSR Growth Inhibition Assay IC50=0.31819 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50=0.32021 μM SANGER
NCI-H209 Growth Inhibition Assay IC50=0.32353 μM SANGER
ChaGo-K-1 Growth Inhibition Assay IC50=0.32489 μM SANGER
KALS-1 Growth Inhibition Assay IC50=0.32594 μM SANGER
D-423MG Growth Inhibition Assay IC50=0.33142 μM SANGER
Detroit562 Growth Inhibition Assay IC50=0.33343 μM SANGER
HT-144 Growth Inhibition Assay IC50=0.3381 μM SANGER
MEG-01 Growth Inhibition Assay IC50=0.34584 μM SANGER
BV-173 Growth Inhibition Assay IC50=0.34596 μM SANGER
MZ7-mel Growth Inhibition Assay IC50=0.34677 μM SANGER
C32 Growth Inhibition Assay IC50=0.34682 μM SANGER
DU-4475 Growth Inhibition Assay IC50=0.34875 μM SANGER
KP-N-YN Growth Inhibition Assay IC50=0.34887 μM SANGER
MKN1 Growth Inhibition Assay IC50=0.35002 μM SANGER
8505C Growth Inhibition Assay IC50=0.35002 μM SANGER
OVCAR-8 Growth Inhibition Assay IC50=0.35584 μM SANGER
NH-12 Growth Inhibition Assay IC50=0.35696 μM SANGER
COR-L88 Growth Inhibition Assay IC50=0.36482 μM SANGER
T-24 Growth Inhibition Assay IC50=0.36985 μM SANGER
MIA-PaCa-2 Growth Inhibition Assay IC50=0.37497 μM SANGER
LS-411N Growth Inhibition Assay IC50=0.37606 μM SANGER
TK10 Growth Inhibition Assay IC50=0.37948 μM SANGER
SW1990 Growth Inhibition Assay IC50=0.38353 μM SANGER
GAMG Growth Inhibition Assay IC50=0.38567 μM SANGER
G-361 Growth Inhibition Assay IC50=0.38712 μM SANGER
Ca-Ski Growth Inhibition Assay IC50=0.38792 μM SANGER
786-0 Growth Inhibition Assay IC50=0.38823 μM SANGER
MHH-NB-11 Growth Inhibition Assay IC50=0.3897 μM SANGER
OE33 Growth Inhibition Assay IC50=0.39118 μM SANGER
SW954 Growth Inhibition Assay IC50=0.40131 μM SANGER
KYSE-180 Growth Inhibition Assay IC50=0.40151 μM SANGER
NCI-H720 Growth Inhibition Assay IC50=0.40191 μM SANGER
COR-L23 Growth Inhibition Assay IC50=0.40286 μM SANGER
PFSK-1 Growth Inhibition Assay IC50=0.41092 μM SANGER
FADU Growth Inhibition Assay IC50=0.41172 μM SANGER
GP5d Growth Inhibition Assay IC50=0.41225 μM SANGER
PC-14 Growth Inhibition Assay IC50=0.41661 μM SANGER
SJSA-1 Growth Inhibition Assay IC50=0.41714 μM SANGER
D-336MG Growth Inhibition Assay IC50=0.42138 μM SANGER
LOXIMVI Growth Inhibition Assay IC50=0.42885 μM SANGER
EFO-27 Growth Inhibition Assay IC50=0.43049 μM SANGER
A2780 Growth Inhibition Assay IC50=0.43162 μM SANGER
CAL-12T Growth Inhibition Assay IC50=0.43288 μM SANGER
ES6 Growth Inhibition Assay IC50=0.44185 μM SANGER
HCE-T Growth Inhibition Assay IC50=0.44187 μM SANGER
SK-MES-1 Growth Inhibition Assay IC50=0.44293 μM SANGER
Daoy Growth Inhibition Assay IC50=0.45103 μM SANGER
A2058 Growth Inhibition Assay IC50=0.45136 μM SANGER
Hs-578-T Growth Inhibition Assay IC50=0.45278 μM SANGER
TE-11 Growth Inhibition Assay IC50=0.45293 μM SANGER
GI-ME-N Growth Inhibition Assay IC50=0.4546 μM SANGER
D-392MG Growth Inhibition Assay IC50=0.45612 μM SANGER
MOLT-13 Growth Inhibition Assay IC50=0.46294 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50=0.46419 μM SANGER
KS-1 Growth Inhibition Assay IC50=0.46603 μM SANGER
HuP-T4 Growth Inhibition Assay IC50=0.46868 μM SANGER
NCI-H1563 Growth Inhibition Assay IC50=0.47035 μM SANGER
U031 Growth Inhibition Assay IC50=0.48234 μM SANGER
HSC-3 Growth Inhibition Assay IC50=0.48626 μM SANGER
HT-3 Growth Inhibition Assay IC50=0.4903 μM SANGER
HGC-27 Growth Inhibition Assay IC50=0.49115 μM SANGER
HT-1080 Growth Inhibition Assay IC50=0.4927 μM SANGER
RT-112 Growth Inhibition Assay IC50=0.49921 μM SANGER
A375 Growth Inhibition Assay IC50=0.49922 μM SANGER
SW626 Growth Inhibition Assay IC50=0.50633 μM SANGER
SBC-5 Growth Inhibition Assay IC50=0.51344 μM SANGER
CAL-51 Growth Inhibition Assay IC50=0.51437 μM SANGER
RKO Growth Inhibition Assay IC50=0.52019 μM SANGER
HC-1 Growth Inhibition Assay IC50=0.52114 μM SANGER
CHL-1 Growth Inhibition Assay IC50=0.52551 μM SANGER
SK-N-DZ Growth Inhibition Assay IC50=0.53078 μM SANGER
SNU-423 Growth Inhibition Assay IC50=0.53466 μM SANGER
NB13 Growth Inhibition Assay IC50=0.53657 μM SANGER
EW-16 Growth Inhibition Assay IC50=0.53774 μM SANGER
A704 Growth Inhibition Assay IC50=0.53881 μM SANGER
Ca9-22 Growth Inhibition Assay IC50=0.54077 μM SANGER
NCI-H1299 Growth Inhibition Assay IC50=0.5558 μM SANGER
LB771-HNC Growth Inhibition Assay IC50=0.55933 μM SANGER
EW-11 Growth Inhibition Assay IC50=0.56326 μM SANGER
LC-2-ad Growth Inhibition Assay IC50=0.56522 μM SANGER
KNS-62 Growth Inhibition Assay IC50=0.56553 μM SANGER
CAL-62 Growth Inhibition Assay IC50=0.57121 μM SANGER
SF126 Growth Inhibition Assay IC50=0.57421 μM SANGER
OMC-1 Growth Inhibition Assay IC50=0.57497 μM SANGER
AGS Growth Inhibition Assay IC50=0.58162 μM SANGER
EW-22 Growth Inhibition Assay IC50=0.58375 μM SANGER
KP-N-YS Growth Inhibition Assay IC50=0.58382 μM SANGER
BFTC-909 Growth Inhibition Assay IC50=0.58833 μM SANGER
PSN1 Growth Inhibition Assay IC50=0.59118 μM SANGER
NB10 Growth Inhibition Assay IC50=0.59129 μM SANGER
COLO-800 Growth Inhibition Assay IC50=0.60328 μM SANGER
647-V Growth Inhibition Assay IC50=0.61787 μM SANGER
VM-CUB-1 Growth Inhibition Assay IC50=0.61861 μM SANGER
OS-RC-2 Growth Inhibition Assay IC50=0.6201 μM SANGER
IST-SL1 Growth Inhibition Assay IC50=0.62788 μM SANGER
NCI-H661 Growth Inhibition Assay IC50=0.63712 μM SANGER
ETK-1 Growth Inhibition Assay IC50=0.63721 μM SANGER
SW1710 Growth Inhibition Assay IC50=0.64023 μM SANGER
GCT Growth Inhibition Assay IC50=0.64935 μM SANGER
SKG-IIIa Growth Inhibition Assay IC50=0.65036 μM SANGER
LU-134-A Growth Inhibition Assay IC50=0.6565 μM SANGER
Becker Growth Inhibition Assay IC50=0.65805 μM SANGER
PANC-08-13 Growth Inhibition Assay IC50=0.66068 μM SANGER
SW620 Growth Inhibition Assay IC50=0.66223 μM SANGER
AsPC-1 Growth Inhibition Assay IC50=0.66361 μM SANGER
LXF-289 Growth Inhibition Assay IC50=0.67625 μM SANGER
RERF-LC-MS Growth Inhibition Assay IC50=0.67671 μM SANGER
NCI-H1355 Growth Inhibition Assay IC50=0.67852 μM SANGER
23132-87 Growth Inhibition Assay IC50=0.68306 μM SANGER
BHY Growth Inhibition Assay IC50=0.68804 μM SANGER
C2BBe1 Growth Inhibition Assay IC50=0.68928 μM SANGER
A172 Growth Inhibition Assay IC50=0.69217 μM SANGER
NCI-H727 Growth Inhibition Assay IC50=0.69812 μM SANGER
NB69 Growth Inhibition Assay IC50=0.70549 μM SANGER
HCC1937 Growth Inhibition Assay IC50=0.70631 μM SANGER
HuCCT1 Growth Inhibition Assay IC50=0.70765 μM SANGER
HH Growth Inhibition Assay IC50=0.70781 μM SANGER
MN-60 Growth Inhibition Assay IC50=0.72124 μM SANGER
CFPAC-1 Growth Inhibition Assay IC50=0.72257 μM SANGER
HOP-62 Growth Inhibition Assay IC50=0.7262 μM SANGER
EW-3 Growth Inhibition Assay IC50=0.73552 μM SANGER
SW1417 Growth Inhibition Assay IC50=0.73593 μM SANGER
NCI-H1155 Growth Inhibition Assay IC50=0.73864 μM SANGER
CAL-54 Growth Inhibition Assay IC50=0.7403 μM SANGER
Saos-2 Growth Inhibition Assay IC50=0.74584 μM SANGER
NCI-H446 Growth Inhibition Assay IC50=0.74806 μM SANGER
LS-513 Growth Inhibition Assay IC50=0.74908 μM SANGER
PA-1 Growth Inhibition Assay IC50=0.74968 μM SANGER
HCC38 Growth Inhibition Assay IC50=0.74984 μM SANGER
DMS-273 Growth Inhibition Assay IC50=0.75456 μM SANGER
U-266 Growth Inhibition Assay IC50=0.76262 μM SANGER
HL-60 Growth Inhibition Assay IC50=0.77355 μM SANGER
UACC-62 Growth Inhibition Assay IC50=0.77553 μM SANGER
DoTc2-4510 Growth Inhibition Assay IC50=0.78211 μM SANGER
SW982 Growth Inhibition Assay IC50=0.78432 μM SANGER
8305C Growth Inhibition Assay IC50=0.78939 μM SANGER
SW48 Growth Inhibition Assay IC50=0.7924 μM SANGER
NB5 Growth Inhibition Assay IC50=0.79651 μM SANGER
J82 Growth Inhibition Assay IC50=0.80487 μM SANGER
HDLM-2 Growth Inhibition Assay IC50=0.81349 μM SANGER
HEC-1 Growth Inhibition Assay IC50=0.81371 μM SANGER
AU565 Growth Inhibition Assay IC50=0.8244 μM SANGER
KYSE-520 Growth Inhibition Assay IC50=0.82636 μM SANGER
HTC-C3 Growth Inhibition Assay IC50=0.83474 μM SANGER
AN3-CA Growth Inhibition Assay IC50=0.83711 μM SANGER
KG-1 Growth Inhibition Assay IC50=0.84484 μM SANGER
NCI-N87 Growth Inhibition Assay IC50=0.84556 μM SANGER
HN Growth Inhibition Assay IC50=0.84591 μM SANGER
SiHa Growth Inhibition Assay IC50=0.85882 μM SANGER
C-33-A Growth Inhibition Assay IC50=0.86185 μM SANGER
A673 Growth Inhibition Assay IC50=0.86536 μM SANGER
HSC-2 Growth Inhibition Assay IC50=0.87334 μM SANGER
LN-405 Growth Inhibition Assay IC50=0.87731 μM SANGER
HOS Growth Inhibition Assay IC50=0.87995 μM SANGER
SF268 Growth Inhibition Assay IC50=0.88097 μM SANGER
DJM-1 Growth Inhibition Assay IC50=0.88602 μM SANGER
HT-29 Growth Inhibition Assay IC50=0.89417 μM SANGER
NCI-H292 Growth Inhibition Assay IC50=0.89777 μM SANGER
UM-UC-3 Growth Inhibition Assay IC50=0.90316 μM SANGER
VMRC-RCZ Growth Inhibition Assay IC50=0.90578 μM SANGER
D-263MG Growth Inhibition Assay IC50=0.90943 μM SANGER
TE-10 Growth Inhibition Assay IC50=0.90984 μM SANGER
SW1088 Growth Inhibition Assay IC50=0.91552 μM SANGER
NCI-H1048 Growth Inhibition Assay IC50=0.91852 μM SANGER
A431 Growth Inhibition Assay IC50=0.92452 μM SANGER
SW1783 Growth Inhibition Assay IC50=0.93251 μM SANGER
NCI-H2452 Growth Inhibition Assay IC50=0.93557 μM SANGER
OAW-42 Growth Inhibition Assay IC50=0.93665 μM SANGER
HuO-3N1 Growth Inhibition Assay IC50=0.94092 μM SANGER
K5 Growth Inhibition Assay IC50=0.94127 μM SANGER
SW1573 Growth Inhibition Assay IC50=0.94227 μM SANGER
NCI-H1792 Growth Inhibition Assay IC50=0.94237 μM SANGER
HCC1187 Growth Inhibition Assay IC50=0.96749 μM SANGER
HCE-4 Growth Inhibition Assay IC50=0.9696 μM SANGER
HPAF-II Growth Inhibition Assay IC50=0.97028 μM SANGER
MEL-HO Growth Inhibition Assay IC50=0.97945 μM SANGER
LCLC-103H Growth Inhibition Assay IC50=0.98027 μM SANGER
CAL-33 Growth Inhibition Assay IC50=0.98378 μM SANGER
NB6 Growth Inhibition Assay IC50=0.98462 μM SANGER
BFTC-905 Growth Inhibition Assay IC50=0.98473 μM SANGER
NMC-G1 Growth Inhibition Assay IC50=0.98592 μM SANGER
RCM-1 Growth Inhibition Assay IC50=0.99258 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50=1.00412 μM SANGER
NCI-H2030 Growth Inhibition Assay IC50=1.01813 μM SANGER
SCC-4 Growth Inhibition Assay IC50=1.01859 μM SANGER
KYSE-410 Growth Inhibition Assay IC50=1.0352 μM SANGER
NCI-H1650 Growth Inhibition Assay IC50=1.03971 μM SANGER
S-117 Growth Inhibition Assay IC50=1.04 μM SANGER
GAK Growth Inhibition Assay IC50=1.05075 μM SANGER
KYSE-450 Growth Inhibition Assay IC50=1.05336 μM SANGER
M059J Growth Inhibition Assay IC50=1.06828 μM SANGER
LAN-6 Growth Inhibition Assay IC50=1.07773 μM SANGER
NCI-H1651 Growth Inhibition Assay IC50=1.09352 μM SANGER
KMOE-2 Growth Inhibition Assay IC50=1.10973 μM SANGER
SN12C Growth Inhibition Assay IC50=1.11785 μM SANGER
SW900 Growth Inhibition Assay IC50=1.12251 μM SANGER
TE-8 Growth Inhibition Assay IC50=1.12291 μM SANGER
HO-1-N-1 Growth Inhibition Assay IC50=1.14353 μM SANGER
BHT-101 Growth Inhibition Assay IC50=1.14714 μM SANGER
639-V Growth Inhibition Assay IC50=1.1667 μM SANGER
RVH-421 Growth Inhibition Assay IC50=1.19347 μM SANGER
SW780 Growth Inhibition Assay IC50=1.19515 μM SANGER
SNB75 Growth Inhibition Assay IC50=1.19819 μM SANGER
U-87-MG Growth Inhibition Assay IC50=1.21334 μM SANGER
TE-1 Growth Inhibition Assay IC50=1.21367 μM SANGER
CAS-1 Growth Inhibition Assay IC50=1.21418 μM SANGER
MKN7 Growth Inhibition Assay IC50=1.21478 μM SANGER
KM-H2 Growth Inhibition Assay IC50=1.21773 μM SANGER
NCI-H1693 Growth Inhibition Assay IC50=1.22758 μM SANGER
KGN Growth Inhibition Assay IC50=1.23359 μM SANGER
NCI-H2347 Growth Inhibition Assay IC50=1.23525 μM SANGER
MFM-223 Growth Inhibition Assay IC50=1.24343 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50=1.26666 μM SANGER
SAS Growth Inhibition Assay IC50=1.26672 μM SANGER
BT-549 Growth Inhibition Assay IC50=1.26782 μM SANGER
NCI-H2228 Growth Inhibition Assay IC50=1.2864 μM SANGER
BxPC-3 Growth Inhibition Assay IC50=1.30672 μM SANGER
SCH Growth Inhibition Assay IC50=1.32503 μM SANGER
GMS-10 Growth Inhibition Assay IC50=1.34551 μM SANGER
GB-1 Growth Inhibition Assay IC50=1.37564 μM SANGER
NCI-H520 Growth Inhibition Assay IC50=1.38168 μM SANGER
GCIY Growth Inhibition Assay IC50=1.39051 μM SANGER
HuH-7 Growth Inhibition Assay IC50=1.39501 μM SANGER
IA-LM Growth Inhibition Assay IC50=1.39986 μM SANGER
BB49-HNC Growth Inhibition Assay IC50=1.40231 μM SANGER
Calu-6 Growth Inhibition Assay IC50=1.41187 μM SANGER
NCI-H650 Growth Inhibition Assay IC50=1.41795 μM SANGER
TE-5 Growth Inhibition Assay IC50=1.41954 μM SANGER
KINGS-1 Growth Inhibition Assay IC50=1.42018 μM SANGER
HCT-116 Growth Inhibition Assay IC50=1.42176 μM SANGER
NCI-H1573 Growth Inhibition Assay IC50=1.42257 μM SANGER
NCI-H358 Growth Inhibition Assay IC50=1.43128 μM SANGER
LNCaP-Clone-FGC Growth Inhibition Assay IC50=1.44319 μM SANGER
KP-4 Growth Inhibition Assay IC50=1.46151 μM SANGER
LK-2 Growth Inhibition Assay IC50=1.46382 μM SANGER
EFM-19 Growth Inhibition Assay IC50=1.48104 μM SANGER
GT3TKB Growth Inhibition Assay IC50=1.48613 μM SANGER
A549 Growth Inhibition Assay IC50=1.48833 μM SANGER
no-11 Growth Inhibition Assay IC50=1.49026 μM SANGER
SK-N-FI Growth Inhibition Assay IC50=1.4938 μM SANGER
NCI-H2170 Growth Inhibition Assay IC50=1.52313 μM SANGER
NCI-H460 Growth Inhibition Assay IC50=1.52961 μM SANGER
NCI-H526 Growth Inhibition Assay IC50=1.53706 μM SANGER
KYSE-510 Growth Inhibition Assay IC50=1.5825 μM SANGER
YKG-1 Growth Inhibition Assay IC50=1.58328 μM SANGER
EW-18 Growth Inhibition Assay IC50=1.60227 μM SANGER
MDA-MB-231 Growth Inhibition Assay IC50=1.6038 μM SANGER
HT55 Growth Inhibition Assay IC50=1.60591 μM SANGER
NCI-H1793 Growth Inhibition Assay IC50=1.61345 μM SANGER
TE-9 Growth Inhibition Assay IC50=1.63456 μM SANGER
DSH1 Growth Inhibition Assay IC50=1.69256 μM SANGER
A101D Growth Inhibition Assay IC50=1.69983 μM SANGER
DB Growth Inhibition Assay IC50=1.70067 μM SANGER
ME-180 Growth Inhibition Assay IC50=1.71785 μM SANGER
BT-20 Growth Inhibition Assay IC50=1.72407 μM SANGER
A498 Growth Inhibition Assay IC50=1.72963 μM SANGER
UMC-11 Growth Inhibition Assay IC50=1.76749 μM SANGER
EC-GI-10 Growth Inhibition Assay IC50=1.77556 μM SANGER
NCI-H630 Growth Inhibition Assay IC50=1.78642 μM SANGER
EGI-1 Growth Inhibition Assay IC50=1.80267 μM SANGER
22RV1 Growth Inhibition Assay IC50=1.80853 μM SANGER
LS-123 Growth Inhibition Assay IC50=1.81214 μM SANGER
OAW-28 Growth Inhibition Assay IC50=1.84746 μM SANGER
CaR-1 Growth Inhibition Assay IC50=1.8707 μM SANGER
HT Growth Inhibition Assay IC50=1.87342 μM SANGER
BCPAP Growth Inhibition Assay IC50=1.88676 μM SANGER
RMG-I Growth Inhibition Assay IC50=1.90787 μM SANGER
C8166 Growth Inhibition Assay IC50=1.90932 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50=1.92035 μM SANGER
SCC-9 Growth Inhibition Assay IC50=1.99105 μM SANGER
EKVX Growth Inhibition Assay IC50=2.00154 μM SANGER
KU-19-19 Growth Inhibition Assay IC50=2.00372 μM SANGER
K-562 Growth Inhibition Assay IC50=2.00898 μM SANGER
SW962 Growth Inhibition Assay IC50=2.04059 μM SANGER
MDA-MB-453 Growth Inhibition Assay IC50=2.05442 μM SANGER
BPH-1 Growth Inhibition Assay IC50=2.07098 μM SANGER
DK-MG Growth Inhibition Assay IC50=2.08603 μM SANGER
Capan-2 Growth Inhibition Assay IC50=2.10041 μM SANGER
SCC-15 Growth Inhibition Assay IC50=2.12541 μM SANGER
DOK Growth Inhibition Assay IC50=2.13147 μM SANGER
YAPC Growth Inhibition Assay IC50=2.15307 μM SANGER
AM-38 Growth Inhibition Assay IC50=2.17015 μM SANGER
EFO-21 Growth Inhibition Assay IC50=2.17788 μM SANGER
A388 Growth Inhibition Assay IC50=2.19271 μM SANGER
RH-18 Growth Inhibition Assay IC50=2.19369 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50=2.19596 μM SANGER
COLO-668 Growth Inhibition Assay IC50=2.29973 μM SANGER
RPMI-2650 Growth Inhibition Assay IC50=2.32659 μM SANGER
HMV-II Growth Inhibition Assay IC50=2.33868 μM SANGER
NCI-H2342 Growth Inhibition Assay IC50=2.34603 μM SANGER
SH-4 Growth Inhibition Assay IC50=2.38204 μM SANGER
L-428 Growth Inhibition Assay IC50=2.38794 μM SANGER
U-118-MG Growth Inhibition Assay IC50=2.39805 μM SANGER
RO82-W-1 Growth Inhibition Assay IC50=2.43727 μM SANGER
NCI-H2291 Growth Inhibition Assay IC50=2.46994 μM SANGER
SK-OV-3 Growth Inhibition Assay IC50=2.50249 μM SANGER
NCI-H441 Growth Inhibition Assay IC50=2.50305 μM SANGER
NCI-H2009 Growth Inhibition Assay IC50=2.52934 μM SANGER
LB2518-MEL Growth Inhibition Assay IC50=2.53747 μM SANGER
PANC-10-05 Growth Inhibition Assay IC50=2.61116 μM SANGER
CAL-85-1 Growth Inhibition Assay IC50=2.66161 μM SANGER
PC-3 Growth Inhibition Assay IC50=2.66611 μM SANGER
COLO-824 Growth Inhibition Assay IC50=2.67374 μM SANGER
D-502MG Growth Inhibition Assay IC50=2.70406 μM SANGER
SBC-1 Growth Inhibition Assay IC50=2.71627 μM SANGER
CAPAN-1 Growth Inhibition Assay IC50=2.71949 μM SANGER
D-247MG Growth Inhibition Assay IC50=2.73756 μM SANGER
CAL-39 Growth Inhibition Assay IC50=2.86389 μM SANGER
NCI-H2087 Growth Inhibition Assay IC50=2.88431 μM SANGER
NB7 Growth Inhibition Assay IC50=2.92139 μM SANGER
NCI-H1437 Growth Inhibition Assay IC50=2.92257 μM SANGER
RD Growth Inhibition Assay IC50=2.99939 μM SANGER
TCCSUP Growth Inhibition Assay IC50=3.02636 μM SANGER
MKN28 Growth Inhibition Assay IC50=3.03463 μM SANGER
NCI-H596 Growth Inhibition Assay IC50=3.0671 μM SANGER
SW948 Growth Inhibition Assay IC50=3.09693 μM SANGER
WM-115 Growth Inhibition Assay IC50=3.11827 μM SANGER
HCC1954 Growth Inhibition Assay IC50=3.12141 μM SANGER
MS-1 Growth Inhibition Assay IC50=3.18474 μM SANGER
SW13 Growth Inhibition Assay IC50=3.2326 μM SANGER
OE19 Growth Inhibition Assay IC50=3.28489 μM SANGER
HT-1197 Growth Inhibition Assay IC50=3.29179 μM SANGER
HLE Growth Inhibition Assay IC50=3.3281 μM SANGER
NUGC-3 Growth Inhibition Assay IC50=3.44761 μM SANGER
UACC-257 Growth Inhibition Assay IC50=3.52417 μM SANGER
SK-MEL-3 Growth Inhibition Assay IC50=3.53214 μM SANGER
KNS-81-FD Growth Inhibition Assay IC50=3.562 μM SANGER
MZ1-PC Growth Inhibition Assay IC50=3.57986 μM SANGER
KLE Growth Inhibition Assay IC50=3.59867 μM SANGER
NCI-H2052 Growth Inhibition Assay IC50=3.60009 μM SANGER
NCI-H1838 Growth Inhibition Assay IC50=3.81119 μM SANGER
NCI-H1623 Growth Inhibition Assay IC50=4.01396 μM SANGER
SCC-25 Growth Inhibition Assay IC50=4.23597 μM SANGER
CP66-MEL Growth Inhibition Assay IC50=4.25191 μM SANGER
TE-12 Growth Inhibition Assay IC50=4.29271 μM SANGER
LU-99A Growth Inhibition Assay IC50=4.31345 μM SANGER
CAMA-1 Growth Inhibition Assay IC50=4.352 μM SANGER
SK-MEL-30 Growth Inhibition Assay IC50=4.41913 μM SANGER
KURAMOCHI Growth Inhibition Assay IC50=4.45528 μM SANGER
BEN Growth Inhibition Assay IC50=4.52362 μM SANGER
NCI-H226 Growth Inhibition Assay IC50=4.54871 μM SANGER
CAL-27 Growth Inhibition Assay IC50=4.71694 μM SANGER
G-401 Growth Inhibition Assay IC50=4.83841 μM SANGER
CAL-120 Growth Inhibition Assay IC50=4.84991 μM SANGER
DMS-114 Growth Inhibition Assay IC50=5.14506 μM SANGER
KYSE-70 Growth Inhibition Assay IC50=5.14859 μM SANGER
NCI-H1648 Growth Inhibition Assay IC50=5.29782 μM SANGER
MDA-MB-175-VII Growth Inhibition Assay IC50=5.44014 μM SANGER
NCI-H2029 Growth Inhibition Assay IC50=5.48022 μM SANGER
LS-1034 Growth Inhibition Assay IC50=5.66889 μM SANGER
LB831-BLC Growth Inhibition Assay IC50=5.70345 μM SANGER
MDA-MB-415 Growth Inhibition Assay IC50=5.7081 μM SANGER
TE-6 Growth Inhibition Assay IC50=5.74182 μM SANGER
SK-MEL-24 Growth Inhibition Assay IC50=5.74564 μM SANGER
HUTU-80 Growth Inhibition Assay IC50=5.75333 μM SANGER
OCUB-M Growth Inhibition Assay IC50=5.77563 μM SANGER
IGR-1 Growth Inhibition Assay IC50=5.86894 μM SANGER
NCI-H747 Growth Inhibition Assay IC50=6.24585 μM SANGER
COLO-680N Growth Inhibition Assay IC50=6.39403 μM SANGER
NB12 Growth Inhibition Assay IC50=6.79722 μM SANGER
SNU-449 Growth Inhibition Assay IC50=6.99591 μM SANGER
D-542MG Growth Inhibition Assay IC50=7.12299 μM SANGER
COLO-792 Growth Inhibition Assay IC50=7.87127 μM SANGER
NCI-H810 Growth Inhibition Assay IC50=8.02984 μM SANGER
T47D Growth Inhibition Assay IC50=8.16024 μM SANGER
Calu-3 Growth Inhibition Assay IC50=8.28886 μM SANGER
COLO-741 Growth Inhibition Assay IC50=8.93093 μM SANGER
LU-135 Growth Inhibition Assay IC50=9.03452 μM SANGER
COLO-678 Growth Inhibition Assay IC50=9.28844 μM SANGER
NCI-H2126 Growth Inhibition Assay IC50=9.33919 μM SANGER
SK-MEL-28 Growth Inhibition Assay IC50=9.53596 μM SANGER
MFE-280 Growth Inhibition Assay IC50=10.0229 μM SANGER
DBTRG-05MG Growth Inhibition Assay IC50=10.4369 μM SANGER
RCC10RGB Growth Inhibition Assay IC50=10.5255 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50=10.6852 μM SANGER
C3A Growth Inhibition Assay IC50=12.3172 μM SANGER
MHH-ES-1 Growth Inhibition Assay IC50=12.5284 μM SANGER
LU-139 Growth Inhibition Assay IC50=12.6333 μM SANGER
KNS-42 Growth Inhibition Assay IC50=12.8771 μM SANGER
MCF7 Growth Inhibition Assay IC50=13.2365 μM SANGER
SW872 Growth Inhibition Assay IC50=14.5461 μM SANGER
HT-1376 Growth Inhibition Assay IC50=14.8582 μM SANGER
NCI-SNU-5 Growth Inhibition Assay IC50=15.1741 μM SANGER
NCI-H2405 Growth Inhibition Assay IC50=15.4474 μM SANGER
KYSE-150 Growth Inhibition Assay IC50=15.7611 μM SANGER
SW837 Growth Inhibition Assay IC50=16.0124 μM SANGER
LU-65 Growth Inhibition Assay IC50=19.726 μM SANGER
JEG-3 Growth Inhibition Assay IC50=20.3577 μM SANGER
SK-MEL-1 Growth Inhibition Assay IC50=20.7836 μM SANGER
SK-HEP-1 Growth Inhibition Assay IC50=21.5541 μM SANGER
NCI-H1770 Growth Inhibition Assay IC50=23.4086 μM SANGER
MG-63 Growth Inhibition Assay IC50=23.7673 μM SANGER
ECC10 Growth Inhibition Assay IC50=25.571 μM SANGER
SW1463 Growth Inhibition Assay IC50=27.8316 μM SANGER
JVM-2 Growth Inhibition Assay IC50=28.3248 μM SANGER
HCT-15 Growth Inhibition Assay IC50=28.4192 μM SANGER
CAL-72 Growth Inhibition Assay IC50=31.4912 μM SANGER
HCC2218 Growth Inhibition Assay IC50=32.8858 μM SANGER
BT-474 Growth Inhibition Assay IC50=33.0843 μM SANGER
NCI-H1092 Growth Inhibition Assay IC50=33.5145 μM SANGER
Mo-T Growth Inhibition Assay IC50=37.3585 μM SANGER
DU-145 Growth Inhibition Assay IC50=40.6295 μM SANGER
NCI-H1666 Growth Inhibition Assay IC50=42.4488 μM SANGER
IST-MES1 Growth Inhibition Assay IC50=46.4196 μM SANGER
SW1116 Growth Inhibition Assay IC50=48.1756 μM SANGER
MZ2-MEL Growth Inhibition Assay IC50=48.5026 μM SANGER

... Click to View More Cell Line Experimental Data

In vivo AZD7762 alone at 25 mg/kg shows little antitumor activity in the H460-DNp53 xenograft mice and SW620 xenograft mice, but when administrated in combination with gemcitabine (60 mg/kg), AZD7762 shows significant antitumor efficacy in the two xenografts mice with a log cell kill of 0.9 or percent treated/control (%T/C) of 26 even at low dose of 12.5 mg. Dosing of AZD7762 in combination with gemcitabine (10 mg/kg) in the H460-DNp53 xenograft rat inhibits the tumor volume in a dose-dependent manner with the %T/C values of 48 and 32 for 10 and 20 mg/kg AZD7762, respectively. AZD7762 (25 mg/kg) in combination with irinotecan (25 or 50 mg/kg) causes complete tumor regression in the SW620 xenograft mice with the %T/C increasing significantly to -66% and -67%, respectively. [1]