 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 587841-73-4 |
| Molecular formula(MF) | C21H19BrClN5O4S2 |
| Molecular Weight(MW): | 584.89 |
| Alias |
| In vitro | DMSO | 100 mg/mL (170.97 mM) |
|---|---|---|
| Water | <1 mg/mL | |
| Ethanol | <1 mg/mL |
| Description | ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM. | ||
|---|---|---|---|
| Targets |
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| In vitro |
ZCL278 inhibits Cdc42 GTPase activity by the competition with GTP and inhibits Rac/Cdc42 phosphorylation in a time-dependent manner. ZCL278 (50 μM) inhibits Cdc42-mediated microspike formation and disrupts GM130-docked Golgi structures in serum-starved Swiss 3T3 fibroblasts. In addition, ZCL278 also suppresses Cdc42-mediated neuronal branching and growth cone dynamics as well as actin-based motility and migration in a metastatic prostate cancer PC-3 cell line without cytotoxicity. [1] |