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GW441756

(CAS No:504433-23-2)

GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2.

CAS No:504433-23-2

Molecular Weight(MW):275.3

Purity:99.00%

Specification:500MG;1G;5G;10G;50G;100G

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QC Documents

COA	MSDS	HPLC	NMR

ChemicalInfomation

CAS No:	504433-23-2
Molecular formula(MF)	C₁₇H₁₃N₃O
Molecular Weight(MW):	275.3
Alias

Solubility

In vitro	DMSO	25 mg/mL (90.81 mM)
	Water	<1 mg/mL
	Ethanol	<1 mg/mL

Biological Activity

Description

GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2.

Targets

TrkA ^[1]	CDK2 ^[1]	C-Raf-1 ^[1]
2 nM	>7 μM	>12 μM

In vitro

GW441756 can specifically block TrkA-induced cell death in a dose-dependent manner. GW441756 can block TrkA-mediated γH2AX production^[2] and apoptosis in TrkA-overexpressing cells. ^[3]