 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 423735-93-7 |
| Molecular formula(MF) | C17H17BrN2O2 |
| Molecular Weight(MW): | 361.23 |
| Alias |
| In vitro | DMSO | 72 mg/mL (199.31 mM) |
|---|---|---|
| Water | <1 mg/mL | |
| Ethanol | <1 mg/mL | |
| In vivo |
| Description | ML-161 is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM. |
|---|---|
| In vitro |
ML-161 is an allosteric inhibitor of PAR1. ML-161 displays dose-dependent inhibition of thrombin-induced platelet activation, as measured by P-selectin expression. ML-161 displays selective inhibition of SFLLRN and thrombin-induced platelet aggregation, both of which operate via PAR1, and has no effect on AYPGKF, thromboxane, or ADP-induced platelet aggregation, which are all agonists at alternative platelet GPCRs. [1] |