 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 379270-37-8 |
| Molecular formula(MF) | C21H29N6O5P |
| Molecular Weight(MW): | 476.47 |
| Alias | (S)-Isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate |
| In vitro | DMSO | 95 mg/mL (199.38 mM) |
|---|---|---|
| Ethanol | 95 mg/mL (199.38 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B. | |
|---|---|---|
| Targets |
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| In vitro |
GS-7340 has a potent anti-HIV activity with IC50 of 0.005 μM. [1] GS 7340 has a half-life of 90 min in human plasma and a half-life of 28.3 min in an MT-2 cell extract at 37°C. [2] the hepatic uptake of GS-7340 isfacilitated by OATP1B1 and OATP1B3, respectively. GS-7340 inhibits HBV reverse transcriptase after being converted to the pharmacologically active form, TFV-DP. [3] |
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| In vivo | In male beagle dogs, GS 7340 (10 mg/kg, p.o.) results in an enhanced distribution to lymphatic tissue. [2] |