 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 328541-79-3 |
| Molecular formula(MF) | C19H15Br2N3O3 |
| Molecular Weight(MW): | 493.15 |
| Alias |
| In vitro | DMSO | 98 mg/mL (198.72 mM) |
|---|---|---|
| Water | <1 mg/mL | |
| Ethanol | <1 mg/mL | |
| In vivo |
| Description | GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM. | ||
|---|---|---|---|
| Targets |
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| In vitro |
GlyH-101 reversibly inhibits CFTR Cl- conductance in <1 min. [1] In rabbit isolated ventricular myocytes, GlyH-101 also blocks cardiac I(Cl.PKA) channels. [2] In transfected FRT (SLC26A9-FRT) cells, GlyH-101 inhibits SLC26A9-mediated Cl- currents. [3] |
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| In vivo | In mice, Topical GlyH-101 (10 μM) in mice rapidly and reversibly inhibits forskolin-induced hyperpolarization in nasal potential differences. In a cholera model, intraluminal GlyH-101 (2.5 μg) reduces cholera toxin-induced intestinal fluid secretion by approximately 80%.[1] |