 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 307538-42-7 |
| Molecular formula(MF) | C11H10BrN3 |
| Molecular Weight(MW): | 264.12 |
| Alias | SMER 28;6-BroMo-N-2-propen-1-yl-4-quinazolinaMine;6-BroMo-N-2-propenyl-4-QuinazolinaMine |
| In vitro | DMSO | 52 mg/mL (196.88 mM) |
|---|---|---|
| Ethanol | 52 mg/mL (196.88 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells. | |
|---|---|---|
| Targets |
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| In vitro |
SMER28 is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. It increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant huntingtin fragments. A marked decrease in Aβ/APP-CTF levels and enhancement for degradation of Aβ/APP-CTF via autophagy is also induced by SMER28. APP-CTF and LC3-II are cocompartmentalized on SMER28 treatment[1]. |