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PR-619

(CAS No:2645-32-1)
PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay.
CAS No:2645-32-1
Molecular Weight(MW):223.28
Purity:98%+
Specification:500mg;1g;5g;10g;50g;100g
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QC Documents
 COA  MSDS  HPLC  NMR
ChemicalInfomation
CAS No: 2645-32-1
Molecular formula(MF) C7H5N5S2
Molecular Weight(MW): 223.28
Alias
Solubility
In vitro DMSO 45 mg/mL (201.54 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo
Biological Activity
Description PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay.
Targets
JOSD2 [1]
(Cell-free assay)
SENP6 core [1]
(Cell-free assay)
UCH-L3 [1]
(Cell-free assay)
USP4 [1]
(Cell-free assay)
USP8 [1]
(Cell-free assay)
1.17 μM(EC50) 2.37 μM(EC50) 2.95 μM(EC50) 3.93 μM(EC50) 4.90 μM(EC50)
In vitro

PR-619 is a cell-permeable pyridinamine class broad-spectrum DUB inhibitor whose known targets include ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37, USP1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. PR-619 are shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150 μM, 0.5 to 20 h). PR619 treatment results in upregulation of both K 48 - and K63-linked polyUb chains. PR-619 induces HCT116 cell death with EC50 values of 6.3 μM.[1]