Home > Products > Proteases > DUB > PR-619

PR-619

(CAS No:2645-32-1)

PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay.

CAS No:2645-32-1

Molecular Weight(MW):223.28

Purity:98%+

Specification:500mg;1g;5g;10g;50g;100g

Price and large packaging, please e-mail consultation:info@SuperLan-chem.com

QC Documents

COA	MSDS	HPLC	NMR

ChemicalInfomation

CAS No:	2645-32-1
Molecular formula(MF)	C₇H₅N₅S₂
Molecular Weight(MW):	223.28
Alias

Solubility

In vitro	DMSO	45 mg/mL (201.54 mM)
	Water	<1 mg/mL
	Ethanol	<1 mg/mL
In vivo

Biological Activity

Description

PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay.

Targets

JOSD2 ^[1] (Cell-free assay)	SENP6 core ^[1] (Cell-free assay)	UCH-L3 ^[1] (Cell-free assay)	USP4 ^[1] (Cell-free assay)	USP8 ^[1] (Cell-free assay)	View More
1.17 μM(EC50)	2.37 μM(EC50)	2.95 μM(EC50)	3.93 μM(EC50)	4.90 μM(EC50)	View More

In vitro

PR-619 is a cell-permeable pyridinamine class broad-spectrum DUB inhibitor whose known targets include ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37, USP1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. PR-619 are shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150 μM, 0.5 to 20 h). PR619 treatment results in upregulation of both K ⁴⁸ - and K⁶³-linked polyUb chains. PR-619 induces HCT116 cell death with EC50 values of 6.3 μM.^[1]