SRPIN 340

(CAS No:218156-96-8)

SRPIN340 is a selective SRPK inhibitor with Ki of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases..

CAS No:218156-96-8

Molecular Weight(MW):349.35

Purity:99.00%

Specification:500MG;1G;5G;10G;50G;100G

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QC Documents

COA	MSDS	HPLC	NMR

ChemicalInfomation

CAS No:	218156-96-8
Molecular formula(MF)	C₁₈H₁₈F₃N₃O
Molecular Weight(MW):	349.35
Alias	di-n-propyl squarate; SR protein phosphorylation inhibitor 1; 3-Cyclobutene-1,2-dione, 3,4-dipropoxy-; CTK2D3599; 1,2-di-n-propoxy-cyclobutenedione; squaric acid dibutyl ester; 3,4-Dipropoxy-3-cyclobuten-1,2-dion;

Solubility

In vitro	DMSO	70 mg/mL (200.37 mM)
	Ethanol	70 mg/mL (200.37 mM)
	Water	<1 mg/mL
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	8 mg/mL

Biological Activity

Description

SRPIN340 is a selective SRPK inhibitor with K_i of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases..

Features

The only specific SRPK1 and SRPK2 inhibitor. Potential use in congenital diseases and viral diseases including HIV, HCV and HBV.

Targets

SRPK1 ^[1]

0.89 μM(Ki)

In vitro

SRPIN340 inhibits SR phosphorylation by SRPK in Flp-In293 cells and promotes degradation of SRp75 in a dose-dependent manner, which subsequently inhibits HIV production. SRPIN340 dose (5 mg/mL) produces no abnormalities in chromosomal structure and chromosome number of CHO cells. ^[1] SRPIN340 suppresses in a dose-dependent fashion expression of a HCV subgenomic replicon and replication of the HCV-JFH1 clone in vitro. ^[2]

In vivo

SRPIN340 inhibits CNV formation in a dose-dependent manner in vivo. SRPIN340 significantly decreases the protein levels of VEGF, MCP-1, ICAM-1, and consequently inhibits macrophage infiltration. ^[3]