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Ro?61-8048

(CAS No:199666-03-0)

Ro 61-8048 is a high-affinity kynurenine 3-hydroxylase (KMO) inhibitor with IC50 and Ki of 37 nM and 4.8 nM, respectively.

CAS No:199666-03-0

Molecular Weight(MW):421.45

Purity:99.00%

Specification:500MG;1G;5G;10G;50G;100G

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QC Documents

COA	MSDS	HPLC	NMR

ChemicalInfomation

CAS No:	199666-03-0
Molecular formula(MF)	C₁₇H₁₅N₃O₆S₂
Molecular Weight(MW):	421.45
Alias

Solubility

In vitro	DMSO	84 mg/mL (199.31 mM)
	Water	<1 mg/mL
	Ethanol	<1 mg/mL
In vivo

Biological Activity

Description

Ro 61-8048 is a high-affinity kynurenine 3-hydroxylase (KMO) inhibitor with IC50 and K_i of 37 nM and 4.8 nM, respectively.

Targets

KMO ^[1]	KMO ^[1]
4.8 nM(Ki)	37 nM

In vivo

In gerbils and rats, Ro 61-8048 (30 mg/kg, p.o.) causes kynurenine 3-hydroxylase inhibition. ^[1] In models of focal or global brain ischemia, Ro 61-8048 (40 mg/kg, p.o.) reduce ischemic brain damage. ^[2] In a hamster model of paroxysmal dyskinesia, Ro 61-8048 (150 mg/kg i.p.) significantly reduces the severity of dystonia without leading to marked central side effects. ^[3] addition, prenatal inhibition of the kynurenine pathway by Ro 61-8048 leads to structural changes in the hippocampus of adult rat offspring. ^[4]