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LLY-507

(CAS No:1793053-37-8)

LLY-507 is a cell-active, potent, and selective inhibitor of protein-lysine Methyltransferase SMYD2.

CAS No:1793053-37-8

Molecular Weight(MW):574.76

Purity:99.00%

Specification:500MG;1G;5G;10G;50G;100G

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COA	MSDS	HPLC	NMR

ChemicalInfomation

CAS No:	1793053-37-8
Molecular formula(MF)	C₃₆H₄₂N₆O
Molecular Weight(MW):	574.76
Alias

Solubility

In vitro	DMSO	100 mg/mL (173.98 mM)
	Ethanol	22 mg/mL (38.27 mM)
	Water	<1 mg/mL
In vivo

Biological Activity

Description

LLY-507 is a cell-active, potent, and selective inhibitor of protein-lysine Methyltransferase SMYD2.

Targets

SMYD2 ^[1]

In vitro

LLY-507 potently inhibits the ability of SMYD2 to methylate p53 peptide with an IC50 <15 nM. LLY-507 is able to potently inhibit the methylation of H4 peptide by SMYD2 enzyme with an IC50 of 31 nM. It has 100-fold selectivity for SMYD2 over 24 other protein or DNA methyltransferases including related family members SMYD3, SUVH420H1, and SUV420H2. LLY-507 inactives (>20 μM) against 454 kinases, 35 G protein-coupled receptors, 14 nuclear hormone receptors, and three cytochrome P450 enzymes. LLY-507 inhibits the proliferation of several esophageal, liver, and breast cancer cell lines in a dose-dependent manner^[1].