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NQDI-1

(CAS No:175026-96-7)

NQDI 1, an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death.

CAS No:175026-96-7

Molecular Weight(MW):319.31

Purity:99.00%

Specification:500MG;1G;5G;10G;50G;100G

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QC Documents

COA	MSDS	HPLC	NMR

ChemicalInfomation

CAS No:	175026-96-7
Molecular formula(MF)	C₁₉H₁₃NO₄
Molecular Weight(MW):	319.31
Alias

Solubility

In vitro	DMSO	21 mg/mL (65.76 mM)
	Water	<1 mg/mL
	Ethanol	<1 mg/mL
In vivo

Biological Activity

Description

NQDI 1, an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death.

Targets

ASK1 ^[1]

In vivo

NQDI 1 inhibits the expression of ASK1 and downstream targets in the HI model. It also inhibits injury and apoptosis in the brain cortex. Intracerebroventricularly injection of NQDI 1 after neonatal rats brain HI significantly attenuates acute HI cerebral injury by inhibiting cell apoptosis. The treatment of NQDI-1 markedly inhibits the expression of ASK1 following HI in the perinatal rat, accompanied by a decrease of p-JNK, p-c-Jun, p53 and caspase 3, which were the downstream targets of ASK1^[1].