 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 1637739-82-2 |
| Molecular formula(MF) | C16H13F3N4O |
| Molecular Weight(MW): | 334.1 |
| Alias |
| In vitro | DMSO | 66 mg/mL warmed (197.54 mM) |
|---|---|---|
| Ethanol | 20 mg/mL warmed (59.86 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA. | |
|---|---|---|
| Targets |
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| In vitro |
In both the H2122 and H358 cell lines, BQU57 inhibits both RalA and RalB activation, and thus causes cell growth inhibition. [1] |
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| In vivo | In mice bearing human lung H2122 tumors, BQU57 (50 mg/kg, i.p.) significantly inhibits activation of both RalA and RalB, and causes dose-dependent tumor growth inhibition. [1] |