 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 1616391-65-1 |
| Molecular formula(MF) | C20H25N5O3 |
| Molecular Weight(MW): | 383.44 |
| Alias |
| In vitro | DMSO | 60 mg/mL warmed (156.47 mM) |
|---|---|---|
| Ethanol | 48 mg/mL warmed (125.18 mM) | |
| Water | <1 mg/mL | |
| In vivo | 2% DMSO+30% PEG 300+ddH2O | 5mg/mL |
| Description | EPZ015666(GSK3235025) is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs. | ||
|---|---|---|---|
| Targets |
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| In vitro |
EPZ015666 shows potent cellular activity that blocks symmetric dimethylation of SmD3 and inhibit proliferation of MCL cell lines (Z-138, Granta-519, Maver-1, Mino, and Jeko-1) with IC50 of 96-904 nM. [1] |
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| In vivo | EPZ015666 (200 mg/kg, p.o.) displays robust anti-tumor activity in MCL xenograft animal models. [1] |