 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 1594094-64-0 |
| Molecular formula(MF) | C23H21In2O3 |
| Molecular Weight(MW): | 500.33 |
| Alias |
| In vitro | DMSO | 100 mg/mL (199.86 mM) |
|---|---|---|
| Ethanol | 4 mg/mL (7.99 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 μM, significant selectivity over KSP. | ||
|---|---|---|---|
| Features | Allosteric, HSET-selective inhibitor. | ||
| Targets |
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| In vitro |
CW069 increases multipolar spindles in N1E-115 cells with supernumerary centrosomes without altering bipolar spindle morphology in normal human dermal fibroblast cells. CW069 inhibits growth in cancer N1E-115 cells with IC50 of 10 μM, but not in NHDF or primary human bone marrow cells. [1] |