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SH-4-54

(CAS No:1456632-40-8)
SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.
CAS No:1456632-40-8
Molecular Weight(MW):610.59
Purity:98%+
Specification:500mg;1g;5g;10g;50g;100g
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QC Documents
 COA  MSDS  HPLC  NMR
ChemicalInfomation
CAS No: 1456632-40-8
Molecular formula(MF) C29H27F5N2O5S
Molecular Weight(MW): 610.59
Alias
Solubility
In vitro DMSO 100 mg/mL (163.77 mM)
Ethanol 50 mg/mL warmed (81.88 mM)
Water <1 mg/mL
In vivo
Biological Activity
Description SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.
Targets
STAT3 [1] STAT5 [1]
300 nM(Kd) 464 nM(Kd)
In vitro

SH-4-54 shows unprecedented cytotoxicity in human glioblastoma brain cancer stem cells (BTSCs), while has no toxicity in human fetal astrocytes. In addition, SH-4-54 effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human 127EF cells Cytotoxic assay 3 days Cytotoxicity against human 127EF cells assessed as cell viability after 3 days by Alamar Blue assay, IC50=66 nM 24900612
human 30M cells Cytotoxic assay 3 days Cytotoxicity against human 30M cells assessed as cell viability after 3 days by Alamar Blue assay, EC50=0.1 μM 24900612
human 84EF cells Cytotoxic assay 3 days Cytotoxicity against human 84EF cells assessed as cell viability after 3 days by Alamar Blue assay, IC50=0.102 μM 24900612
human 67EF cells Cytotoxic assay 3 days Cytotoxicity against human 67EF cells assessed as cell viability after 3 days by Alamar Blue assay, IC50=0.106 μM 24900612
human 73EF cells Cytotoxic assay 3 days Cytotoxicity against human 73EF cells assessed as cell viability after 3 days by Alamar Blue assay, IC50=0.162 μM 24900612
human 25EF cells Cytotoxic assay 3 days Cytotoxicity against human 25EF cells assessed as cell viability after 3 days by Alamar Blue assay, IC50=0.234 μM 24900612
human 73M cells Cytotoxic assay 3 days Cytotoxicity against human 73M cells assessed as cell viability after 8 days by Alamar Blue assay, IC50=1.03 μM 24900612
human 147EF cells Function assay 2-72 h Inhibition of STAT3 in human 147EF cells assessed as reduction of phosphorylated cyclin D1 level after 2 to 72 hrs by Western blotting analysis 24900612

... Click to View More Cell Line Experimental Data

In vivo In mice orthotopically xenografted with BT73, SH-4-54 (10 mg/kg i.p.) exhibits BBB permeability, potently suppresses glioma tumor growth, and inhibits pSTAT3. [1]