YYA-021
(CAS No:144217-65-2)
QC Documents
ChemicalInfomation
| CAS No: |
144217-65-2 |
| Molecular formula(MF) |
C18H27N3O2 |
| Molecular Weight(MW): |
317.43 |
| Alias |
|
Solubility
| In vitro |
DMSO
|
0.01 mg/mL
(0.03 mM)
|
|
Water
|
<1 mg/mL
|
|
Ethanol
|
<1 mg/mL
|
| In vivo |
|
|
Biological Activity
| Description |
YYA-021 is a CD4-mimic HIV entry inhibitor, competitively inhibiting the interaction between gp120 and CD4. |
|
Targets
|
|
| In vitro |
YYA-021 enhances the neutralization sensitivity of simian-human immunodeficiency virus (SHIV) carrying the envelope from the clade B clinical human immunodeficiency virus type 1 (HIV-1) isolate MNA. [1]
|
| In vivo |
In rats and rhesus macaques, YYA-021 (i.v.) shows moderate half-lives, wide tissue distribution and relatively high distribution volumes. [2]
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COA
HPLC