 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 1440209-96-0 |
| Molecular formula(MF) | C16H16N2O3 |
| Molecular Weight(MW): | 284.31 |
| Alias |
| In vitro | DMSO | 56 mg/mL (196.96 mM) |
|---|---|---|
| Ethanol | 9 mg/mL warmed (31.65 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | BRD73954 is a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively. | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Targets |
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| In vitro |
As compared to the other class I and II histone deacetylases (HDACs) (HDAC1, 12 μM; HDAC2, 9 μM; HDAC3, 23μM; HDAC4, >33 μM; HDAC5, >33 μM; HDAC7, 13 μM; HDAC8, 120 nM; HDAC9, >33 μM), BRD73954 maintains excellent selectivity toward HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively. Treatment with BRD73954 results in a robust increase in α -tubulin acetylation. [1] |