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ZM241385

(CAS No:139180-30-6)
ZM-241385 is a high affinity antagonist ligand selective for the adenosine A2A receptor.
CAS No:139180-30-6
Molecular Weight(MW):337.34
Purity:99.00%
Specification:500MG;1G;5G;10G;50G;100G
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QC Documents
 COA  MSDS  HPLC  NMR
ChemicalInfomation
CAS No: 139180-30-6
Molecular formula(MF) C16H15N7O2
Molecular Weight(MW): 337.34
Alias
Solubility
In vitro DMSO 67 mg/mL (198.61 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo
Biological Activity
Description ZM-241385 is a high affinity antagonist ligand selective for the adenosine A2A receptor.
Targets
adenosine A2A receptor [3]
In vitro

ZM 241385 has high affinity for A2a receptors. In rat phaeochromocytoma cell membranes, ZM 241385 displaces binding of tritiated 5'-N-ethylcarboxamidoadenosine (NECA) with a pIC50 of 9.52[3]. ZM241385 delays the appearance of anoxic depolarization (AD), a phenomenon strictly related to cell damage and death, protect from the synaptic activity depression brought about by a severe (7 min) OGD period, and protect CA1 neuron and astrocyte from injury[4].

In vivo ZM-241385 significantly blunts the hypotensive effects of CCPA and NECA without altering the bradycardia induced by these agonists. It blocks the infarct size-reducing effects(cardioprotective effects) of this two distinct adenosine receptor agonists[1].