 COA |
MSDS |
 HPLC |
NMR |
| CAS No: | 1314890-29-3 |
| Molecular formula(MF) | C25H21F3N4O3S |
| Molecular Weight(MW): | 514.52 |
| Alias |
| In vitro | DMSO | 100 mg/mL (194.35 mM) |
|---|---|---|
| Ethanol | 2 mg/mL warmed (3.88 mM) | |
| Water | <1 mg/mL | |
| In vivo |
| Description | TMP269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively. | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Targets |
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| In vitro |
TMP269 has no impact on the mitochondrial activity and/or the viability of human CD4+ T cells at 10 μM, and may be used as tools to identify the endogenous substrates of the class IIa HDAC enzymes. [1] In IEC-18 intestinal epithelial cells, TMP269 prevents cell cycle progression, DNA synthesis, and proliferation induced in response to G protein-coupled receptor/PKD1 activation. [2] |