Home > Products > Neuronal Signaling > GluR > VU0364439

VU0364439

(CAS No:1246086-78-1)

VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.

CAS No:1246086-78-1

Molecular Weight(MW):422.29

Purity:98%+

Specification:500mg;1g;5g;10g;50g;100g

Price and large packaging, please e-mail consultation:info@SuperLan-chem.com

QC Documents

COA	MSDS	HPLC	NMR

ChemicalInfomation

CAS No:	1246086-78-1
Molecular formula(MF)	C₁₈H₁₃Cl₂N₃O₃S
Molecular Weight(MW):	422.29
Alias

Solubility

In vitro	DMSO	85 mg/mL (201.28 mM)
	Water	<1 mg/mL
	Ethanol	<1 mg/mL

Biological Activity

Description

VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.

Features

The most potent mGlu4 PAM reported to date.

Targets

mGluR4 ^[1]

19.8 nM(EC50)

In vivo

VU 0364439 possess less than ideal PK properties preventing their use as in vivo tools. It shows better stability in HLM (63% remaining) than RLM (2% remaining). ^[1]