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FH535

(CAS No:108409-83-2)
FH535 is a Wnt/β-catenin signaling inhibitor and also a dual PPARγ and PPARδ antagonist.
CAS No:108409-83-2
Molecular Weight(MW):361.20
Purity:98%+
Specification:500mg;1g;5g;10g;50g;100g
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QC Documents
 COA  MSDS  HPLC  NMR
ChemicalInfomation
CAS No: 108409-83-2
Molecular formula(MF) C13H10Cl2N2O4S
Molecular Weight(MW): 361.20
Alias
Solubility
In vitro DMSO 72 mg/mL warmed (199.33 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo
Biological Activity
Description FH535 is a Wnt/β-catenin signaling inhibitor and also a dual PPARγ and PPARδ antagonist.
Targets
Wnt/β-catenin [1] PPARγ [1] PPARδ [1]
In vitro

FH535 antagonizes β-Catenin/Tcf–mediated transcription, and inhibits recruitment of the coactivators GRIP1 and β-catenin to PPARδ and PPARγ. FH535 shows selective anti-proliferation effect on some cancer cells expressing high or active Wnt/β-catenin pathway. [1] FH535 increases cigarette smoke condensate cytotoxicity, and causes changes in β-catenin and EGR-1 signaling. [2] FH535 has potential therapeutic value in treatment of liver cancer by targeting liver cancer stem cells and hepatocellular carcinoma cell lines. [3]